Hyperpolarized 89Y Complexes as pH Sensitive NMR Probes
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چکیده
منابع مشابه
Hyperpolarized 89Y complexes as pH sensitive NMR probes.
Hyperpolarization can increase the sensitivity of NMR/MRI experiments, but the primary limitation is the T(1) decay of magnetization. Due to its long T(1), the hyperpolarized (89)Y nucleus makes an excellent candidate as an in vivo spectroscopy/imaging probe. Here we report the (89)Y chemical shift dependence upon pH for two hyperpolarized (89)Y(III) complexes and demonstrate how such complexes...
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Experimental measurements and theoretical analysis of magnetic properties, structural dynamics and acid-base equilibria for several lanthanide(III) complexes with tetraazacyclododecane derivatives as 19F NMR chemical shift pH probes are presented; pKa values vary between 6.9 and 7.7, with 18 to 40 ppm chemical shift differences between the acidic and basic forms for Ho(III) complexes possessing...
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INTRODUCTION The intrinsically low sensitivity of NMR can be overcome by dynamic nuclear polarization (DNP), However, a fundamental limitation in the use of hyperpolarized materials is the signal decay due to T1 relaxation. Among NMR-active nuclei, Y offers a number of attractive features. It is 100% abundant, it has spin 1⁄2, and it has a long T1, up to 10 min. Y is potentially valuable in med...
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ژورنال
عنوان ژورنال: Journal of the American Chemical Society
سال: 2010
ISSN: 0002-7863,1520-5126
DOI: 10.1021/ja910278e